2 deoxyglucose toxicity

    Fludeoxyglucose F 18 Injection (FDG): Side Effects .

    Mar 03, 2017· Fludeoxyglucose F 18 Injection (fdg) is a positron emitting radiopharmaceutical containing no-carrier added radioactive 2-deoxy-2-[18 F]fluoro-D-g1ucose, which is used for diagnostic purposes in conjunction with Positron Emission Tomography (PET). …

    Acute Toxicity and Cardio-Respiratory Effects of 2-Deoxy-D .

    Objective To evaluate the acute toxicity of 2-deoxy-D-glucose (2DG) by oral (p.o.) and intravenous (i.v.) routes, and also the cardio-respiratory effects following high doses of 2DG in animal models. Methods The LD50 of 2DG (in water) was determined in rats and mice by p.o. route and in mice by i.v. route.

    Aldo‐keto reductases‐mediated cytotoxicity of 2 .

    Cytotoxicity of AKR substrates depends on their catalytic efficiency of AKR1B1/AKR1B10 and the cellular levels of glutathione (GSH). A, Enzyme activity assay. B,C, Comparison of the toxicity of 2‐deoxyglucose (2DG), diacetyl and glyceraldehyde, redrawn with part of the data from Figure 4 and Figure S1. **P < .01 vs 2DG group.

    Targeted Cancer Therapy with a 2-Deoxyglucose–Based .

    In this study, a new active receptor-mediated complex, ADM conjugated with 2-amino-2-deoxy-d-glucose and succinic acid (2DG–SUC–ADM), was designed to target tumor cells through glucose transporter 1 (GLUT1). MTT assay and confocal images showed that the complex had better inhibition rate to tumor cells and low toxicity to normal cells.

    (PDF) The multi-drug resistance phenotype: 31P NMR .

    The 2-DG inhibits early steps of glycolysis, the main energy-pro toxicity of 2-deoxyglucose, a glucose antimetabolite, was investigated in ducing pathway in cancer cells (11-14). Therefore, the effect of addition to the NMR studies and was found to be consistently higher in 2-DG on cell growth was compared for a variety of drug- multidrug .

    Genetic Analysis of Resistance and Sensitivity to 2 .

    Oct 01, 2014· Further, we show that the relative toxicity of 2-deoxyglucose is carbon source dependent, as is the resistance conferred by gene deletions. [Snf1][1] kinase, the AMP-activated protein kinase of yeast, is required for 2-deoxyglucose resistance in cells growing on glucose.

    Expression of LKB1 tumor suppressor in non-small cell lung .

    vented 2-deoxyglucose mediated apoptosis, demonstrating the critical role of LKB1 in mediating 2-deoxyglucose toxicity. Conclusions: LKB1 loss increases susceptibility to 2-deoxyglucose treatment in non-small cell lung cancer lines, even at low doses. Thus, determination of LKB1 status may help direct therapy to those patients most likely to

    2-Deoxy-D-glucose - Wikipedia

    2-Deoxy-d-glucose is a glucose molecule which has the 2-hydroxyl group replaced by hydrogen, so that it cannot undergo further glycolysis. As such; it acts to competitively inhibit the production of glucose-6-phosphate from glucose at the phosphoglucoisomerase level (step 2 of glycolysis).

    Acute toxicity and cardio-respiratory effects of 2-deoxy-D .

    To evaluate the acute toxicity of 2-deoxy-D-glucose (2DG) by oral (p.o.) and intravenous (i.v.) routes, and also the cardio-respiratory effects following high doses of 2DG in animal models.

    A phase I dose-escalation trial of 2- deoxy- d-glucose .

    Methods. A modified accelerated titration design was used. 2DG was administered orally once daily for 7 days every other week starting at a dose of 2 mg/kg and docetaxel was administered intravenously at 30 mg/m 2 for 3 of every 4 weeks beginning on day 1 of week 2. Following the completion of dose escalation, cohorts of patients were then treated with 2DG for 21 days or every day of each 4 .

    IJMS | Free Full-Text | Rescue of 2-Deoxyglucose Side .

    Cancer metabolism is characterized by extensive glucose consumption through aerobic glycolysis. No effective therapy exploiting this cancer trait has emerged so far, in part, due to the substantial side effects of the investigated drugs. In this study, we examined the side effects of a combination of isocaloric ketogenic diet (KD) with the glycolysis inhibitor 2-deoxyglucose (2-DG).

    Deoxyglucose | Psychology Wiki | FANDOM powered by Wikia

    2-Deoxyglucose has been proposed by Garriga-Canut et al. as a mimic for the ketogenic diet, and shows great promise as a new anti-epileptic drug. The authors suggest that 2-DG works, in part, by decreasing the expression of Brain-derived neurotrophic factor (BDNF). Such uses are complicated by the fact that 2-deoxyglucose does have some toxicity.

    2-Deoxy-d-Glucose (2-DG)-Induced Cardiac Toxicity in Rat .

    2-Deoxy-d-glucose (2-DG) is being developed as a potential anticonvulsant and disease-modifying agent for patients with epilepsy; however, during preclinical development, cardiac toxicity has been encountered in rats.

    (PDF) FINDING A ROLE FOR 2-DEOXYGLUCOSE IN CANCER …

    PDF | 2-D-Deoxyglucose (2dg) is a synthetic, non-metabolizable glucose analogue that blocks glycolysis and glucose utilization in the cell, thus restricting energy production. It has been tested .

    Evaluation of 2-deoxy- D -glucose as a chemotherapeutic .

    Sep 23, 2002· Kaplan O, Lyon R, Faustino P, Straka E, Cohen J (1990a) Effects of 2-deoxyglucose on drug-sensitive and drug-resistant human breast cancer cells: toxicity and magnetic resonance spectroscopy of .

    2 deoxyglucose toxicity,

    Determination of Glucose Utilization Rates in Cultured .

    Abstract. 2-Deoxy-d-[14 C]glucose ([14 C]DG) is commonly used to determine local glucose utilization rates (CMR glc) in living brain and to estimate CMR glc in cultured brain cells as rates of [14 C]DG phosphorylation.Phosphorylation rates of [14 C]DG and its metabolizable fluorescent analog, 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose (2-NBDG), however, do not take into .

    2-Deoxyglucose Reverses the Promoting Effect of Insulin on .

    An increased risk of colorectal cancer is related to the development of metabolic syndromes including hyperglycemia, and hyperinsulinemia. The high circulatory levels of glucose and/or insulin or the application of exogenous insulin may promote carcinogenesis, cancer progression and metastasis, which can be attributed to the Warburg effect or aerobic glycolysis.

    Under normoxia, 2-deoxy-d-glucose elicits cell death in .

    In tumor cells growing under hypoxia, inhibiting glycolysis with 2-deoxy-d-glucose (2-DG) leads to cell death, whereas under normoxic conditions cells similarly treated survive. Surprisingly, here we find that 2-DG is toxic in select tumor cell lines growing under normal oxygen tension. In contrast, a more potent glycolytic inhibitor, 2-fluorodeoxy-d-glucose, shows little or no toxicity in .

    2-Deoxy-D-Glucose - an overview | ScienceDirect Topics

    2-Deoxyglucose uptake in conjunction with electrical stimulation of rat motor cortex has been extensively studied by Sharp (5).Therefore, using parameters similar to those of Sharp, we designed a double-label experiment in which the forelimb region of motor cortex in the rat was electrically stimulated first on the right side following the [14 C]2-DG injection and then on the left side .

    Mechanism of Toxicity in Rotenone Models of Parkinson's .

    Nov 26, 2003· Although rotenone caused modest ATP depletion, equivalent ATP loss induced by 2-deoxyglucose was without toxicity, arguing that bioenergetic defects were not responsible for cell death. In contrast, reducing oxidative damage with antioxidants, or by …

    Selective Uptake of [14C]2-Deoxyglucose by Neurons and .

    We used [14 C]2-deoxyglucose (2DG), which is an analog of glucose and is not metabolized further than the first phosphorylation by hexokinase; this property allows localization of the tracer within the cell type where it is phosphorylated. The present technical approach associated a method of cellular trajectography mainly characterized by the .

    2-Fluoro-2-deoxyglucose 6-phosphate | C6H12FO8P - PubChem

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    2-Deoxy-D-glucose - Wikipedia

    2-Deoxy-d-glucose is a glucose molecule which has the 2-hydroxyl group replaced by hydrogen, so that it cannot undergo further glycolysis. As such; it acts to competitively inhibit the production of glucose-6-phosphate from glucose at the phosphoglucoisomerase level (step 2 of glycolysis).

    The wonders of 2-deoxy-d-glucose - Xi - 2014 - IUBMB Life .

    The wonders of 2-deoxy-d-glucose. Authors. Haibin Xi, . et al. (2012) 2-Deoxyglucose-induced toxicity is regulated by bcl-2 family members and is enhanced by antagonizing bcl . Jiangwei Li, Hong Zhao, Zbigniew Darzynkiewicz, Synergy of 2-deoxy-d-glucose combined with berberine in inducing the lysosome/autophagy and transglutaminase .

    Deoxyglucose | C6H12O5 - PubChem

    Therapeutically, 2-deoxyglucose is an investigational drug that is being studied as an anticancer and antiviral agent. Concerning the former, 2- deoxyglucose was used as an adjunct to chemotherapy and radiotherapy in the treatment of solid tumors (lung, breast, pancreas, head, neck, and gastric tumors).

    Under normoxia, 2-deoxy-d-glucose elicits cell death in .

    Nov 01, 2007· In tumor cells growing under hypoxia, inhibiting glycolysis with 2-deoxy-d-glucose (2-DG) leads to cell death, whereas under normoxic conditions cells similarly treated survive. Surprisingly, here we find that 2-DG is toxic in select tumor cell lines growing under normal oxygen tension. In contrast, a more potent glycolytic inhibitor, 2-fluorodeoxy-d-glucose, shows little or no toxicity in .

    Substance Name: 2-Deoxy-D-glucose

    154-17-6 - VRYALKFFQXWPIH-PBXRRBTRSA-N - 2-Deoxy-D-glucose - Similar structures search, synonyms, formulas, resource links, and other chemical information.

    2 deoxyglucose toxicity,

    Aldo‐keto reductases‐mediated cytotoxicity of 2 .

    2-deoxyglucose, AKR1B1, AKR1B10, glutathione (GSH), oxidative stress 1 | INTRODUCTION 2-Deoxyglucose (2DG) is a mild anticancer drug that is being tested in clinical trials to determine its efficacy to augment chemotherapy and radiotherapy. The cytotoxicity of 2DG is not as severe as some of the anticancer drugs. However, its specificity in .

    Expression of LKB1 tumor suppressor in non-small cell lung .

    vented 2-deoxyglucose mediated apoptosis, demonstrating the critical role of LKB1 in mediating 2-deoxyglucose toxicity. Conclusions: LKB1 loss increases susceptibility to 2-deoxyglucose treatment in non-small cell lung cancer lines, even at low doses. Thus, determination of LKB1 status may help direct therapy to those patients most likely to

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